PathoPic – image database / PathoPic ID 10265 - Histiozytose eines Lymphknotens mit Metallabrieb

Die ausgeprägte makrophagenreiche Fremdkörperreaktion zerstört die Lymphknotenarchitektur. Makrophagen mit teils reichlichem Zytoplasma enthalten schwarzen fein granulären Metallabrieb.

Polyethylene particles, identified by their characteristic needle-like shape and bright birefringence under polarized light, within macrophages and multinucleated giant cells.

Vergrösserter inguinaler Lymphknoten. Hüftprothese.

Particles generated by the mechanical wear of a prosthesis can leave the site of the implant through lymphatic vessels and become engulfed by macrophages within the local and regional lymph nodes. The accumulation of cells containing particles causes the enlargement of a lymph node and the characteristic histological appearance of sinus histiocytosis.
J Bone Joint Surg Am. 1996 Apr;78(4):588-93. Lymphadenopathy associated with total joint prostheses. A report of two cases and a review of the literature. Benz EB, Sherburne B, Hayek JE, Falchuk KH, Sledge CB, Spector M. PMID: 8609139
Pathol Res Pract. 2004;200(3):189-96. Foreign body reactions in lymph nodes of oncology patients with joint prostheses--light-, electron microscopic and immunohistological investigations. Bos I, Johannisson R. PMID: 15200270